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Article

Role of global regulators and nucleotide metabolism in antibiotic tolerance in Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Aug 2008

Hansen Sonja, Lewis Kim, Vulić Marin

Abstract excerpt

Bacterial populations produce a small number of persister cells that exhibit multidrug tolerance. Persister cells are largely responsible for the antibiotic recalcitrance of biofilm infections. The mechanism of persister cell formation largely remains unknown due to the challenges in identifying persister genes. We screened an ordered comprehensive library of 3,985 Escherichia coli knockout strains to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18519731
DOI: 10.1128/AAC.00144-08
PMCID: PMC2493092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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