Article

Optimization of novel compounds using computer-aided drug design for treatment of cardiac arrhythmia

2025-06-25

Abstract excerpt

Loss-of-function mutations of the voltage-gated K + channels KCNQ1/KCNE1 can lead to cardiac arrhythmia such as Long QT Syndrome, which is characterized by a prolonged QT interval in the electrocardiogram. One potential strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the physiological duration of the action potential. However, there are currently...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af666739-f7c2-5dd4-995e-125b3744ff51
DOI: 10.22541/au.175085290.08341568/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optimization of novel compounds using computer-aided drug design for treatment of cardiac arrhythmiaDOI 10.22541/au.175085290.08341568/v1Read

Mechanistic understanding of KCNQ1 activating polyunsaturated fatty acid analogs.Semantic proximity Read

Mechanistic insights into robust cardiac I <sub>Ks</sub> potassium channel activation by aromatic polyunsaturated fatty acid analoguesSemantic proximity Read

Large-Scale Structure-Based Virtual Screening Identifies Diverse K <sub>Na</sub> 1.1 (KCNT1) Potassium Channel InhibitorsSemantic proximity Read

Polyunsaturated fatty acid analogues differentially affect cardiac Na <sub>v</sub> , Ca <sub>v</sub> , and K <sub>v</sub> channels through unique mechanismsSemantic proximity Read

A comprehensive structural model for the human KCNQ1/KCNE1 ion channel.Semantic proximity Read

Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval.Semantic proximity Read

High-throughput screening identifies a trafficking corrector for long QT syndrome-associated KCNQ1 variants.Semantic proximity Read

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.Semantic proximity Read

High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 VariantsSemantic proximity Read

The I Ks Ion Channel Activator Mefenamic Acid Requires KCNE1 and Modulates Channel Gating in a Subunit-Dependent Manner.Semantic proximity Read

Lipophilic compounds restore function to neurodevelopmental-associated KCNQ3 mutations.Semantic proximity Read

Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening.Semantic proximity Read