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Article

IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2003

Teige Ingrid, Treschow Alexandra, Teige Anna, Mattsson Ragnar, Navikas Vaidrius, Leanderson Tomas, Holmdahl Rikard, Issazadeh-Navikas Shohreh

Abstract excerpt

Since the basic mechanisms behind the beneficial effects of IFN-beta in multiple sclerosis (MS) patients are still obscure, here we have investigated the effects of IFN-beta gene disruption on the commonly used animal model for MS, experimental autoimmune encephalomyelitis (EAE). We show that IFN...

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Share to Adjuvants, Immunologic
Share to Adoptive Transfer
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12707359
DOI: 10.4049/jimmunol.170.9.4776

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12707359-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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