Article
Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis.
Cell reports - 3 Jan 2017
Gao Han, Danzi Matt C, Choi Claire S, Taherian Mehran, Dalby-Hansen Camilla, Ellman Ditte G, Madsen Pernille M, Bixby John L, Lemmon Vance P, Lambertsen Kate L, Brambilla Roberta
Abstract excerpt
In multiple sclerosis (MS), soluble tumor necrosis factor (TNF) is detrimental via activation of TNF receptor 1 (TNFR1), whereas transmembrane TNF is beneficial primarily by activating TNF receptor 2 (TNFR2). Here, we investigate the role of TNFR2 in microglia and monocytes/macrophages in experimental autoimmune encephalomyelitis (EAE), a model of MS, by cell-specific gene targeting. We show that TNFR2 ablation...
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