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High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures

12 Feb 2024

Abstract excerpt

BACKGROUND: Excessive energy intake in modern society has led to an epidemic surge in metabolic diseases, such as obesity and type 2 diabetes, posing profound threats to women's reproductive health. However, the precise impact and underlying pathogenesis of energy excess on female reproduction remain unclear. METHODS: We established an obese and hyperglycemic female mouse model induced by a high-fat and...

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Share to Ovarian function and disorders
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PMID: 38347623
DOI: 10.1186/s12967-024-04952-y

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