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Article

Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes in sex-dependent and sex-independent manners.

GeroScience - 1 Jun 2024

Zhu Yun, Engmann Morgan, Medina David, Han Xiuqi, Das Pratyusa, Bartke Andrzej, Ellsworth Buffy S, Yuan Rong

Abstract excerpt

Metformin has attracted increasing interest for its potential benefits in extending healthspan and longevity. This study examined the effects of early-life metformin treatment on the development and metabolism of C57BL/6 J (B6) mice, with metformin administered to juvenile mice from 15 to 56 days of age. Metformin treatment led to decreased body weight in both sexes (P < 0.05, t-test). At 9 weeks of age, mice...

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Identifiers

PMID: 38227136
DOI: 10.1007/s11357-024-01067-6
PMCID: PMC11009201

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