Article
Females are protected from semaglutide-induced muscle loss in <i>ob/ob</i> mice
2026-03-05
Abstract excerpt
Obesity is a major contributor to cardiometabolic disease, and pharmacological therapies such as semaglutide are increasingly used to induce weight loss. However, the commonly used diet-induced obesity model in C57BL/6J mice is limited by relative resistance to weight gain in females, complicating the study of sex-specific effects. Here, we used leptin-deficient ob/ob mice, which develop severe early-onset obesit...
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Identifiers and source
- Literature Corpus work
- fb660be8-5981-5685-9584-26747a05ab4b
- DOI
- 10.64898/2026.03.03.709376