Article

Transgenic pyrimethamine-resistant <i>P. falciparum</i> reveals transmission blocking potency of P218, a novel antifolate

2020-09-06

Abstract excerpt

Antimalarial drug which target more than one life stage of the parasite are valuable tools in the fight against malaria. Previous generation of antifolate drugs are able to inhibit replicative stages of drug-sensitive, but not resistant parasites in humans, and mosquitoes. The lack of reliable gametocyte-producing, antifolate resistant P. falciparum hindrance the development of new antifolate compounds against mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e36cd44-f36d-51b7-b8af-e33b615db36e
DOI: 10.1101/2020.09.06.284786

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transgenic pyrimethamine-resistant <i>P. falciparum</i> reveals transmission blocking potency of P218, a novel antifolateDOI 10.1101/2020.09.06.284786Read

Transgenic pyrimethamine-resistant plasmodium falciparum reveals transmission-blocking potency of P218, a novel antifolate candidate drug.Semantic proximity Read

New insights into antimalarial chemopreventive activity of antifolatesSemantic proximity Read

CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission researchSemantic proximity Read

Generation of Transgenic Human Malaria Parasites With Strong Fluorescence in the Transmission StagesSemantic proximity Read

A versatile, marker-free platform for life cycle-wide imaging in <i>Plasmodium falciparum</i> via integration of an exogenous gene cassette into a conserved intergenic locusSemantic proximity Read

Dihydrofolate Reductase as a Target for Chemotherapy in ParasitesSemantic proximity Read

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetSemantic proximity Read

Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model.Semantic proximity Read

Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax.Semantic proximity Read

Highly efficient site-specific mutagenesis in Malaria mosquitoes using CRISPRSemantic proximity Read

Efficient generation of mNeonGreen Plasmodium falciparum reporter lines enables quantitative fitness analysisSemantic proximity Read

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?Semantic proximity Read