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Dihydrofolate Reductase as a Target for Chemotherapy in Parasites

1 Feb 2007

Abstract excerpt

Opportunistic infections are known to cause morbidity and mortality in immunocompromised individuals. In addition, serious infections due to several parasites are also known to affect the quality and duration of life in normal individuals. The importance of dihydrofolate reductase (DHFR) in parasitic chemotherapy arises from its function in DNA biosynthesis and cell replication. DHFR catalyzes the reduction of...

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PMID: 17346178
DOI: 10.2174/138161207780162827

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