Article

New insights into antimalarial chemopreventive activity of antifolates

2021-08-18

Abstract excerpt

Antifolates targeting dihydrofolate reductase (DHFR) are antimalarial compounds that have long been used for malaria treatment and chemoprevention (inhibition of infection from mosquitoes to humans). Despite their extensive applications, the thorough understanding of antifolate activity against hepatic malaria parasites, especially resistant parasites, have yet to be achieved. Using a transgenic P. berghei harbor...

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Literature Corpus work: 46fae99e-23c9-58d4-8935-23b329d3a3e8
DOI: 10.1101/2021.08.17.456746

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