Article

Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes

2017-01-01

Abstract excerpt

Human islet amyloid polypeptide (hIAPP), also known as amylin, is the main constituent of the amyloid deposits present in approximately 95% of people with type 2 diabetes. Amylin aggregates into oligo-/polymeric sheet structures which are considered to be cytotoxic to pancreatic -cells. Inhibiting the early stages of amylin aggregation could provide a potential therapeutic strategy for the treatment of type 2 diab...

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Literature Corpus work: 8e35cf2d-b3b7-563b-88b2-82207c8285e4
DOI: 10.17635/lancaster/thesis/149

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