Article

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

2020-05-26

Abstract excerpt

Human islet amyloid polypeptide (hIAPP, or amylin) is a 37 amino acid hormone secreted by pancreatic islet β-cells. Aggregation of hIAPP into amyloid fibrils is found in more than 90% of Type-II Diabetes (T2D) patients and is considered to be associated with T2D pathology. Although different models have been proposed, the high resolution structure of hIAPP fibrils is unknown. Here we report the cryo-EM structure o...

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Literature Corpus work: f88b59f3-cd80-5a76-8e03-3c11d76796f5
DOI: 10.1101/2020.05.25.114967

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