Article

Reversible 2’-OH Acylation Enhances RNA Stability

2022-04-26

Abstract excerpt

<title>Abstract</title> <p>Stabilization of RNAs for storage, transport, and biological application remains a serious challenge, particularly for larger RNAs that are not accessible by chemical synthesis. Here, we present reversible 2’-OH acylation as a general strategy to preserve RNA of any length or origin. High-yield polyacylation of 2’-hydroxyls (“cloaking”) by readily accessible acylimidazole reagents effec...

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Literature Corpus work: 8e32ddf3-01e9-5399-a413-5de4a4a66e66
DOI: 10.21203/rs.3.rs-1483354/v1

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