Article

Engineering site-specific nucleic acid-protein conjugates by utilizing a natural RNAylation reaction

2025-07-16

Abstract excerpt

Nucleic acid-protein conjugates are valuable for synthetic biology, therapeutics, and nanotechnology, but current methods often lack site specificity and rely on non-natural linkages. RNAylation, a one-step enzymatic reaction catalyzed by the bacteriophage T4 enzyme ModB where first discovered in vivo during phage infection, enables site-specific conjugation of nucleic acids to proteins via a natural N-glycosidic...

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Literature Corpus work: a098a688-9296-53af-ba02-6c864c6841c6
DOI: 10.1101/2025.07.11.664405

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