Article

Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent RNA Modulation

2026-01-16

Abstract excerpt

<h4>ABSTRACT</h4> RNA remains a largely untapped target for covalent small-molecule intervention due to the lack of electrophiles with predictable reactivity and stability in biological settings. Here, a mechanistically defined and tunable class of epoxide- and aziridine-2-carboxamide electrophiles that enable structure-guided covalent targeting of RNA is described. These warheads arise from an unexpected hydroly...

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Literature Corpus work: be132ebb-b0d5-5c56-934c-9fbfda9b0cff
DOI: 10.64898/2026.01.15.699758

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Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent RNA ModulationDOI 10.64898/2026.01.15.699758Read

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