Article

Nature-Inspired Chemical Probes for in-cell Labeling of Lipidized RNA and Identification of New Regulatory Enzymes

2022-05-17

Abstract excerpt

RNA modifications play pivotal roles in numerous cellular processes and human diseases. In addition to well-studied methyl-based modifications, hydrophobic prenyl-modifications have also been found in many RNA species. Here we report two chemical labeling strategies for tagging lipid-modified RNAs by taking advantage of a natural SelU-mediated tRNA geranylation process and the special reactivity of prenyl-groups....

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Literature Corpus work: 99bf9fbd-bf38-51b7-8f6f-ab177497aec5
DOI: 10.1101/2022.05.17.492276

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