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XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection

16 Nov 2022

Abstract excerpt

The unprecedented emergence and spread of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, underscores the need for diagnostic and therapeutic technologies that can be rapidly tailored to novel threats. Here, we show that site-specific RNA endonuclease XNAzymes - artificial catalysts composed of single-stranded synthetic xeno-nucleic acid oligonucleotides (in this case...

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PMID: 36385143
DOI: 10.1038/s41467-022-34339-w

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