Article

A single-cell genetic colocalization test improves power and resolves disease-mediating cell types

2025-10-13

Abstract excerpt

Statistical colocalization testing methods can determine if the same single-nucleotide polymorphism (SNP) underlies both a genome-wide association study (GWAS) locus as well as an expression quantitative trait (eQTL) locus. This can nominate potential mechanistic pathways from SNPs to genes to traits, while providing cell type or tissue context. Surprisingly, systematic colocalization testing with bulk-tissue eQTL...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3382ea02-1e18-5df3-800c-8ff73786e103
DOI: 10.1101/2025.10.10.681685

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single-cell genetic colocalization test improves power and resolves disease-mediating cell typesDOI 10.1101/2025.10.10.681685Read

Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation.Semantic proximity Read

Probabilistic colocalization of genetic variants from complex and molecular traits: promise and limitations.Semantic proximity Read

Colocalization of expression transcripts with COVID-19 outcomes is rare across cell states, cell types and organsSemantic proximity Read

Probabilistic Colocalization of Genetic Variants from Complex and Molecular Traits: Promise and LimitationsSemantic proximity Read

Identification of putative effector genes across the GWAS Catalog using molecular quantitative trait loci from 68 tissues and cell typesSemantic proximity Read

Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular diseaseSemantic proximity Read

Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease.Semantic proximity Read

An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatmentSemantic proximity Read

Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell dataSemantic proximity Read

Estimating colocalization probability from limited summary statistics.Semantic proximity Read

Conditional polygenic enrichment distinguishes causal from tagging disease-critical cell populations in single-cell RNA-seqSemantic proximity Read

Estimating colocalization probability from limited summary statisticsSemantic proximity Read