Article

Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and Retina

2021-03-31

Abstract excerpt

Hypothalamic inflammation and sympathetic nervous system hyperactivity are hallmark features of metabolic syndrome and type 2 diabetes. Hypothalamic inflammation may aggravate metabolic and immunologic pathologies due to extensive sympathetic activation of peripheral tissues. Loss of somatostatinergic (SST) neurons may contribute to enhanced hypothalamic inflammation. The present data show that leptin receptor def...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e2f0a39-96a6-5b3a-b6ee-b6e472fe4b3b
DOI: 10.1101/2021.03.30.437706

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Depleting Hypothalamic Somatostatinergic Neurons Recapitulates Diabetic Phenotypes in Brain, Bone Marrow, Adipose, and RetinaDOI 10.1101/2021.03.30.437706Read

Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control.Semantic proximity Read

Tanycyte-Independent Control of Hypothalamic Leptin SignalingSemantic proximity Read

Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to ObesitySemantic proximity Read

Ablation of Neurons Expressing Melanin-Concentrating Hormone (MCH) in Adult Mice Improves Glucose Tolerance Independent of MCH SignalingSemantic proximity Read

New insights into the role and origin of pituitary S100β-positive cellsSemantic proximity Read

The distinct characteristics of somatostatin neurons in the human brainSemantic proximity Read

Depressive-like behaviors induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiationSemantic proximity Read

Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balanceSemantic proximity Read

Somatostatin receptors and autoimmune-mediated diabetes.Semantic proximity Read

Anorexia and impaired glucose metabolism in mice with hypothalamic ablation of Glut4 neurons.Semantic proximity Read

Internalization-defective mutants of somatostatin receptor subtype 2 exert normal signaling functions in hematopoietic cells.Semantic proximity Read

Truncated somatostatin receptors as new players in somatostatin–cortistatin pathophysiologySemantic proximity Read