Article
Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control.
Cell metabolism - 10 May 2016
Djogo Tina, Robins Sarah C, Schneider Sarah, Kryzskaya Darya, Liu Xiaohong, Mingay Andrew, Gillon Colleen J, Kim Joo Hyun, Storch Kai-Florian, Boehm Ulrich, Bourque Charles W, Stroh Thomas, Dimou Leda, Kokoeva Maia V
Abstract excerpt
While leptin is a well-known regulator of body fat mass, it remains unclear how circulating leptin is sensed centrally to maintain energy homeostasis. Here we show that genetic and pharmacological ablation of adult NG2-glia (also known as oligodendrocyte precursors), but not microglia, leads to primary leptin resistance and obesity in mice. We reveal that NG2-glia contact the dendritic processes of arcuate...
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