Article

Directed Differentiation of Human iPSCs to Functional Ovarian Granulosa-Like Cells via Transcription Factor Overexpression

2022-07-04

Abstract excerpt

An in vitro model of human ovarian follicles would greatly benefit the study of female reproduction. Ovarian development requires the combination of germ cells and their supporting somatic cells, known as granulosa cells. Whereas efficient protocols exist for generating human primordial germ cell-like cells (hPGCLCs) from human iPSCs, a method of generating granulosa cells has been elusive. Here we report that si...

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Literature Corpus work: 8e1cc9d4-0db1-59e6-a198-62ec6838562a
DOI: 10.1101/2022.07.04.498717

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