Article

Reconstitution of human fetal ovaries reveals niche requirements for primordial germ cell-like cell progression

2025-03-24

Abstract excerpt

<h4>SUMMARY</h4> Human primordial germ cell-like cells (hPGCLCs) can be specified from human induced pluripotent stem cells (hiPSCs), offering a valuable model for human germ cell development. However, further maturation steps of hPGCLCs rely on mouse feeders, or co-culture with mouse gonadal somatic cells. Exposure of hPGCLCs to human embryonic niche has not been attempted. Here, we co-cultured female hPGCLCs in...

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Literature Corpus work: 400c84d3-edad-5f39-97b4-f9b4e7eb904c
DOI: 10.1101/2025.03.21.644608

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