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Single-cell RNA-seq identified novel genes involved in primordial follicle formation

11 Dec 2023

Abstract excerpt

Introduction: The number of primordial follicles (PFs) in mammals determines the ovarian reserve, and impairment of primordial follicle formation (PFF) will cause premature ovarian insufficiency (POI). Methods: By analyzing public single-cell RNA sequencing performed during PFF on mice and human ovaries, we identified novel functional genes and novel ligand-receptor interaction during PFF. Based on...

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PMID: 38149096
DOI: 10.3389/fendo.2023.1285667

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