Article

Identification of Gene Conversion Events in Horse IGHV Suggests Preferential Hotspots for Diversification

2026-02-16

Abstract excerpt

<title>Abstract</title> <p>The humoral immune response relies on a diverse antibody repertoire, which is generated through V(D)J recombination in B lymphocytes. This repertoire is then expanded further by processes such as somatic hypermutation, gene conversion and class-switch recombination, which are primarily mediated by activation-induced cytidine deaminase (AID). Gene conversion is the main generator of dive...

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Literature Corpus work: 8e1ca90a-6adc-5649-8ed0-dff60ef185ff
DOI: 10.21203/rs.3.rs-8799402/v1

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