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Diversification of immunoglobulin genes by gene conversion in the domestic chicken (Gallus gallusdomesticus)

1 Jan 2023

Abstract excerpt

Sustainable modern poultry production depends on effective protection against infectious diseases and a diverse range of antibodies is key for an effective immune response. In the domestic chicken, somatic gene conversion is the dominant process in which the antibody immunoglobulin genes are diversified. Affinity maturation by somatic hypermutation (SHM) also occurs, but the relative contribution of gene...

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PMID: 38567069
DOI: 10.1093/discim/kyad002

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