Article
Immunoglobulin heavy chain variable region analysis in dairy goats.
Immunobiology - 1 Nov 2018
Du Lijuan, Wang Shuhui, Zhu Yanjiao, Zhao Haidong, Basit Abdul, Yu Xiaohui, Li Qingwang, Sun Xiuzhu
Abstract excerpt
Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into two gene families based on sequence similarity. By analyzing the IgH cDNA sequences, we further...
Topics
- Animals
- DNA, Complementary
- Evolution, Molecular
- Genome
- Goats
- Horses
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Mutation