Article

PPARβ/δ controls Mediator recruitment and transcription initiation

2019-01-24

Abstract excerpt

Repression of transcription by nuclear receptors involves NCOR and SMRT corepressor complexes, which harbour the deacetylase HDAC3 as a subunit. Both deacetylase-dependent and -independent repression mechanisms have been reported for these complexes. In the absence of ligands, the nuclear receptor PPARβ/δ recruits NCOR and SMRT and represses expression of its canonical targets including the ANGPTL4 gene. Agonisti...

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Literature Corpus work: 8e149df2-e991-52db-9bb6-c9a2c830f16b
DOI: 10.1101/525576

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