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Article

A dominant negative PPARgamma mutant shows altered cofactor recruitment and inhibits adipogenesis in 3T3-L1 cells.

Diabetologia - 1 Mar 2003

Park Y, Freedman B D, Lee E J, Park S, Jameson J L

Abstract excerpt

AIMS/HYPOTHESIS: PPARgamma, a member of the nuclear hormone receptor family of transcription factors, plays a key role in adipocyte differentiation and insulin sensitivity. The aim of this study was to identify a potential dominant negative murine PPARgamma mutant and to characterize the in vitro functional properties of this mutant. METHODS: In vitro transient transfections and mammalian two-hybrid assays in...

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Identifiers

PMID: 12687335
DOI: 10.1007/s00125-003-1037-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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