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PPARγ Cistrome Repression during Activation of Lung Monocyte-Macrophages in Severe COVID-19

25 Sept 2020

Abstract excerpt

The molecular mechanisms of cytokine storm in patients with severe COVID-19 infections are poorly understood. To uncover these events, we performed transcriptome analyses of lung biopsies from patients with COVID-19, revealing a gene enrichment pattern similar to that of PPARγ-knockout macrophages. Single-cell gene expression analysis of bronchoalveolar lavage fluids revealed a characteristic trajectory of...

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PMID: 33015591
DOI: 10.1016/j.isci.2020.101611

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