Article

Pioneer factor Foxa2 enables ligand-dependent activation of LXRα

2020-04-10

Abstract excerpt

<h4>Summary</h4> Type II nuclear hormone receptors, such as FXR, LXR, and PPAR, which function in glucose and lipid metabolism and serve as drug targets for metabolic diseases, are permanently positioned in the nucleus regardless of the ligand status. Ligand activation of these receptors is thought to occur by co-repressor/co-activator exchange, followed by initiation of transcription. However, recent genome-wide...

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Literature Corpus work: 06433b8b-7b74-5352-897c-3978ecc42507
DOI: 10.1101/2020.04.10.036061

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