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Article

The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor γ requires G protein pathway suppressor 2.

The Journal of biological chemistry - 6 Feb 2015

Guo Chun, Li Yali, Gow Chien-Hung, Wong Madeline, Zha Jikun, Yan Chunxia, Liu Hongqi, Wang Yongjun, Burris Thomas P, Zhang Jinsong

Abstract excerpt

Repression of peroxisome proliferator-activated receptor γ (PPARγ)-dependent transcription by the nuclear receptor corepressor (NCoR) is important for homeostatic expression of PPARγ target genes in vivo. The current model states that NCoR-mediated repression requires its direct interaction with PPARγ in the repressive conformation. Previous studies, however, have shown that DNA-bound PPARγ is incompatible with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25519902
DOI: 10.1074/jbc.M114.598797
PMCID: PMC4319032

Genes

GPS2

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