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Article

Reverse crosstalk of TGFβ and PPARβ/δ signaling identified by transcriptional profiling

15 Sept 2010

Abstract excerpt

Previous work has provided strong evidence for a role of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) and transforming growth factor-β (TGFβ) in inflammation and tumor stroma function, raising the possibility that both signaling pathways are interconnected. We have addressed this hypothesis by microarray analyses of human diploid fibroblasts induced to myofibroblastic differentiation, which revealed a...

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PMID: 20846954
DOI: 10.1093/nar/gkq773

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