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Article

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

29 Jun 2015

Abstract excerpt

BACKGROUND: The peroxisome proliferator-activated receptor alpha (PPARα) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARα-tr was suggested to exert a dominant negative function despite being unable to bind consensus PPARα DNA response elements. METHODS: The distribution and variability factor of each PPARα variant were assessed in the well-characterized cohort of...

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PMID: 26122096
DOI: 10.1186/s12885-015-1500-x

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