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The essential role of TTC28 in maintaining chromosomal stability via HSPA8 chaperone-mediated autophagy

4 Dec 2024

Abstract excerpt

There are three distinct forms of autophagy, namely, macroautophagy, microautophagy, and HSPA8 chaperone-mediated autophagy (CMA). While macroautophagy is widely recognized as a regulator of chromosomal instability (CIN) through various pathways, the contributions of CMA and microautophagy to CIN remain uncertain. TTC28 , a conserved gene in vertebrates, is frequently mutated and down-regulated in numerous human...

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PMID: 39630868
DOI: 10.1073/pnas.2409447121

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