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Single-nucleus multi-omic profiling of polyploid heart nuclei identifies fusion-derived cardiomyocytes in the human heart.

2024-05-30

Abstract excerpt

<title>Abstract</title> <p>Understanding the mechanisms of polyploidization in cardiomyocytes is crucial for advancing strategies to stimulate myocardial regeneration. Although endoreplication has long been considered the primary source of polyploid human cardiomyocytes, recent animal work suggests the potential for cardiomyocyte fusion. Moreover, the effects of polyploidization on the genomic-transcriptomic repe...

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Literature Corpus work
8dfe3d1e-dd51-5e89-844a-e3b78a2c404f
DOI
10.21203/rs.3.rs-4414468/v1
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