Article

Somatic mutations in single human cardiomyocytes demonstrate accelerated age-related DNA damage and cell fusion

2020-10-07

Abstract excerpt

<title>Abstract</title> <p>The accumulation of somatic DNA mutations is a hallmark of aging in many dividing cells and contributes to carcinogenesis. Here we survey the landscape of somatic single-nucleotide variants (sSNVs) in heart muscle cells (cardiomyocytes) which normally do not proliferate but often become polyploid with age. Using single-cell whole-genome sequencing we analyzed sSNVs from 48 single cardio...

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Literature Corpus work: 0f725738-0090-527e-abe6-2f95aa8b3f60
DOI: 10.21203/rs.3.rs-84503/v1

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