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Article

Integrated multi-omic characterization of congenital heart disease.

Nature - 1 Aug 2022

Hill Matthew C, Kadow Zachary A, Long Hali, Morikawa Yuka, Martin Thomas J, Birks Emma J, Campbell Kenneth S, Nerbonne Jeanne, Lavine Kory, Wadhwa Lalita, Wang Jun, Turaga Diwakar, Adachi Iki, Martin James F

Abstract excerpt

The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of patients with CHD survive into adulthood, but many suffer premature death from heart failure and non-cardiac causes1. Here, to gain insight into this disease progression, we performed single-nucleus RNA sequencing on 157,273...

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Share to Cardiomyopathy, Dilated
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Myocytes, Cardiac

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Source

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Identifiers

PMID: 35732239
DOI: 10.1038/s41586-022-04989-3
PMCID: PMC10405779

Genes

CRIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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