Polyploid cardiomyocytes define disease-specific transcriptional states in the mammalian heart

Abstract excerpt

The adult mammalian heart has a limited regenerative capacity. Following injury, cardiomyocytes undergo a hypertrophic response accompanied by polyploidization, which has been described as a barrier to proliferation and regeneration of the heart 1,2 . However, the unique molecular programs of polyploidy, or genome multiplied cardiomyocytes, and their influence on the disease-related myocardial remodelling process...

Topics

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• Cardiomyopathy and Myosin Studies
• Cardiomyopathy, Dilated
• Cardiomyopathy, Hypertrophic
• Congenital heart defects research
• Heart Defects, Congenital
• Myocytes, Cardiac
• RNA-Seq
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

2f11deba-5463-5b18-8dc9-9db9e93c586c

DOI

10.64898/2026.01.31.701472