Article

HIF-1α Contributes to the Progression of Chronic Obstructive Pulmonary Disease

2022-01-09

Abstract excerpt

<h4>Background</h4> Hypoxia-inducible factor-1α (HIF-1α) plays an important regulatory role in inflammatory and hypoxic diseases. Higher HIF-1α level was found in lungs of chronic obstructive pulmonary disease (COPD) patients, however, its role in cigarette smoke (CS)-induced COPD has not been fully studied. Digoxin has been showed to inhibit HIF-1α translation and block HIF-1α activity and thus is often used as...

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Literature Corpus work: 8df8aa12-b2fc-5678-a920-571f923441aa
DOI: 10.1101/2022.01.09.472256

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