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Novel phosphodiesterase-4 inhibitor mufemilast protects against smoke inhalation-induced lung injury

2026-08-27

Abstract excerpt

<title>Abstract</title> <p>Introduction: Smoke inhalation injury (SII) is a leading cause of acute lung injury and subsequent fibrotic remodeling, yet effective targeted therapies remain limited. Phosphodiesterase 4 (PDE4) signaling has been implicated in inflammatory and fibrotic lung diseases; however, its contribution to SII pathogenesis remains poorly understood. Objectives This study aimed to elucidate the...

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Literature Corpus work: d88ba771-184a-5f3f-aa04-7c247b6b79e2
DOI: 10.21203/rs.3.rs-10644113/v1

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