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Alpha-1 antitrypsin protects against phosgene-induced acute lung injury by activating the ID1-dependent anti-inflammatory response

2022-12-05

Abstract excerpt

Phosgene, a highly dangerous chemical warfare agent, is widely used as an industrial chemical. Phosgene inhalation causes acute lung injury (ALI), which may further progress into pulmonary edema. Currently, there is no known antidote for phosgene poisoning. Alpha-1 antitrypsin (α1-AT) is a protease inhibitor that has been used to treat emphysema patients, who are deficient in α1-AT, for decades. Recent studies hav...

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Literature Corpus work
455c22be-cf0e-5abe-93a5-823cd3c4f33f
DOI
10.21203/rs.3.rs-2324070/v1
Open publication

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Alpha-1 antitrypsin protects against phosgene-induced acute lung injury by activating the ID1-dependent anti-inflammatory responseDOI 10.21203/rs.3.rs-2324070/v1
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