Article

HIF-1α inhibitor protects against cigarette smoke-induced COPD development in mice

2024-01-02

Abstract excerpt

<title>Abstract</title> <p>Hypoxia-inducible factor-1α (HIF-1α) plays an important regulatory role in inflammatory and hypoxic diseases. Higher HIF-1α level was found in lungs of chronic obstructive pulmonary disease (COPD) patients, however, its role in cigarette smoke (CS)-induced COPD has not been fully studied. Digoxin has been showed to inhibit HIF-1α translation and block HIF-1α activity and thus is often u...

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Literature Corpus work: 255c8a91-9d27-5e5c-8674-97373199a452
DOI: 10.21203/rs.3.rs-3789467/v1

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