Article

Cell type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells

2023-07-28

Abstract excerpt

The functional impact and cellular context of mosaic structural variants (mSVs) in normal tissues is understudied. Utilizing Strand-seq, we sequenced 1,133 single cell genomes from 19 human donors of increasing age, revealing a heterogeneous mSV landscape in hematopoietic stem and progenitor cells (HSPCs). While mSV clonal expansions are confined to individuals over 60, de novo mSV formation occurs consistently a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8de5f109-c2d9-5f50-97a9-18e40620bffc
DOI: 10.1101/2023.07.25.550502

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cellsDOI 10.1101/2023.07.25.550502Read

Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells.Semantic proximity Read

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Semantic proximity Read

Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs.Semantic proximity Read

Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue.Semantic proximity Read

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.Semantic proximity Read

Comprehensive benchmarking of somatic mutation detection by the SMaHT NetworkSemantic proximity Read

Dissecting single-cell genomes through the clonal organoid technique.Semantic proximity Read

Somatic genomics as a discovery engine for biomedicine.Semantic proximity Read

The Somatic Mosaicism across Human Tissues Network.Semantic proximity Read

Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis.Semantic proximity Read

Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cellsSemantic proximity Read

Multiplex generation and single-cell analysis of structural variants in mammalian genomes.Semantic proximity Read