Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting single-cell genomes through the clonal organoid technique.

Experimental & molecular medicine - 1 Oct 2021

Youk Jeonghwan, Kwon Hyun Woo, Kim Ryul, Ju Young Seok

Abstract excerpt

The revolution in genome sequencing technologies has enabled the comprehensive detection of genomic variations in human cells, including inherited germline polymorphisms, de novo mutations, and postzygotic mutations. When these technologies are combined with techniques for isolating and expanding single-cell DNA, the landscape of somatic mosaicism in an individual body can be systematically revealed at a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Genomics

Share to Mutation

Share to Organoids

Share to Single-cell and spatial transcriptomics

Source

Open in PubMed Open full text

Identifiers

PMID: 34663940
DOI: 10.1038/s12276-021-00680-1
PMCID: PMC8569207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting single-cell genomes through the clonal organoid technique.PMID 34663940Read ↗

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures.Semantic proximity Read ↗

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Semantic proximity Read ↗

Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcriptsSemantic proximity Read ↗

Analyzing somatic mutations by single-cell whole-genome sequencing.Semantic proximity Read ↗

The Somatic Mosaicism across Human Tissues Network.Semantic proximity Read ↗

A comprehensive view of somatic mosaicism by single-cell DNA analysisSemantic proximity Read ↗

Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations and mRNA Transcripts.Semantic proximity Read ↗

Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagusSemantic proximity Read ↗

Somatic Mosaicism in Biology and Disease.Semantic proximity Read ↗

Human embryonic genetic mosaicism and its effects on development and disease.Semantic proximity Read ↗

Mosaicism in health and disease - clones picking up speed.Semantic proximity Read ↗

Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.