Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue.

American journal of human genetics - 3 Mar 2016

Vattathil Selina, Scheet Paul

Abstract excerpt

Genomic mosaicism arising from post-zygotic mutation has recently been demonstrated to occur in normal tissue of individuals ascertained with varied phenotypes, indicating that detectable mosaicism may be less an exception than a rule in the general population. A challenge to comprehensive cataloging of mosaic mutations and their consequences is the presence of heterogeneous mixtures of cells, rendering...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human
Share to Computational Biology
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Genetic Loci

Share to Genome, Human

Share to Genomics

Share to Mosaicism

Source

Open in PubMed Open full text

Identifiers

PMID: 26942289
DOI: 10.1016/j.ajhg.2016.02.003
PMCID: PMC4800050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue.PMID 26942289Read ↗

Patterns of mosaicism for sequence and copy-number variants discovered through clinical deep sequencing of disease-related genes in one million individuals.Semantic proximity Read ↗

A genomic view of mosaicism and human disease.Semantic proximity Read ↗

Mosaicism in health and disease - clones picking up speed.Semantic proximity Read ↗

MosaicBase: A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Disease-related and Healthy Human Individuals.Semantic proximity Read ↗

Mosaicism in Human Health and Disease.Semantic proximity Read ↗

Somatic mosaicism: implications for disease and transmission genetics.Semantic proximity Read ↗

The Somatic Mosaicism across Human Tissues Network.Semantic proximity Read ↗

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Semantic proximity Read ↗

MosaicBase: A Knowledgebase of Postzygotic Mosaic Variants in Noncancer Diseases and Asymptomatic Human IndividualsSemantic proximity Read ↗

Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging.Semantic proximity Read ↗

Detecting somatic mosaicism: considerations and clinical implications.Semantic proximity Read ↗

Comprehensive benchmarking of somatic structural variant detection at ultra-low allele fractionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.