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Article

From gut to pancreas: Shared genetic susceptibility and biological convergence in acute pancreatitis and Crohn's disease.

PloS one - 1 Jan 2026

Xu Wenbin, Ji Aocheng, Han Lu, Xiong Hao, Jin Yiyi, Lin Wen, Wu Yonghui, Wang Yun, Zhong Huan, Xiong Longxin, Zeng Chunyan

Abstract excerpt

BACKGROUND: Acute pancreatitis (AP) and Crohn's disease (CD) exhibit overlapping clinical presentations and an unexpectedly high rate of comorbidity. Whether this reflects shared genetic susceptibilities remains unclear. METHODS: We performed a cross-trait genome-wide association analysis leveraging European-ancestry summary statistics for AP (Ncases = 8446; Ncontrols = 437,418) and CD (Ncases = 12,194;...

Read the complete abstract on PubMed

Topics

Humans
Crohn Disease
Genetic Predisposition to Disease
Pancreatitis
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Linkage Disequilibrium

Pancreas

Bayes Theorem

Source

Open in PubMed Open full text

Identifiers

PMID: 42726709
DOI: 10.1371/journal.pone.0353031
PMCID: PMC13567791

Genes

ATG16L1
FADS1
FADS2
IRGM
PRKAA1
RSPO3
SMAD3
ZPBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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