Article
Extraintestinal manifestations and complications in inflammatory bowel disease: from shared genetics to shared biological pathways.
Inflammatory bowel diseases - 1 Jun 2014
van Sommeren Suzanne, Janse Marcel, Karjalainen Juha, Fehrmann Rudolf, Franke Lude, Fu Jingyuan, Weersma Rinse K
Abstract excerpt
BACKGROUND: The clinical presentation of the inflammatory bowel diseases (IBD) is extremely heterogenous and is characterized by various extraintestinal manifestations and complications (EIM). Increasing genetic insight for IBD and EIM shows multiple shared susceptibility loci. We hypothesize that, next to these overlapping genetic risk loci, distinct disease pathways are shared between IBD and EIM. METHODS: The...
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