Article
Dissecting causal relationships between primary biliary cholangitis and extrahepatic autoimmune diseases based on Mendelian randomization.
Scientific reports - 21 May 2024
Ma Gang, Yang Jiaqi, Wang Xingguo, Xia Erzhuo, Yu Jiahao, Zhang Miao, Hu Yinan, Ma Shuoyi, Zhou Xia, Fan Qingling, Han Ying, Wang Jingbo
Abstract excerpt
As an autoimmune disease, up to 73% of patients with primary biliary cholangitis (PBC) have a combination of extrahepatic autoimmune diseases (EHAIDs); however, the causal relationship between PBC and EHAIDs is unclear. The genome-wide association analyses provided 14 GWAS data for PBC and EHAIDs, and bidirectional, two-sample MR analyses were performed to examine the relationship between PBC and EHAIDs. The...
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