Article
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
Nature genetics - 1 May 2016
Ellinghaus David, Jostins Luke, Spain Sarah L, Cortes Adrian, Bethune Jörn, Han Buhm, Park Yu Rang, Raychaudhuri Soumya, Pouget Jennie G, Hübenthal Matthias, Folseraas Trine, Wang Yunpeng, Esko Tonu, Metspalu Andres, Westra Harm-Jan, Franke Lude, Pers Tune H, Weersma Rinse K, Collij Valerie, D'Amato Mauro, Halfvarson Jonas, Jensen Anders Boeck, Lieb Wolfgang, Degenhardt Franziska, Forstner Andreas J, Hofmann Andrea, Schreiber Stefan, Mrowietz Ulrich, Juran Brian D, Lazaridis Konstantinos N, Brunak Søren, Dale Anders M, Trembath Richard C, Weidinger Stephan, Weichenthal Michael, Ellinghaus Eva, Elder James T, Barker Jonathan N W N, Andreassen Ole A, McGovern Dermot P, Karlsen Tom H, Barrett Jeffrey C, Parkes Miles, Brown Matthew A, Franke Andre
Abstract excerpt
We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more than 86,000 individuals of European ancestry, we identified 244 independent multidisease signals, including 27 new...
Topics
- Bayes Theorem
- Cholangitis, Sclerosing
- Chronic Disease
- Colitis, Ulcerative
- Comorbidity