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Article

Polygenic Risk Scores Show Distinct Genetic Architectures of IBD-Associated Comorbidities.

Digestive diseases and sciences - 1 Nov 2026

Easwar Tejas, Wanchaitanawong Wasuwit, Ananthakrishnan Ashwin N

Abstract excerpt

BACKGROUND AND AIMS: Patients with inflammatory bowel disease (IBD) have a higher prevalence of various immune and non-immune comorbidities. Whether this reflects shared genetic susceptibility or is an effect of chronic inflammation remains unclear. METHODS: We systematically assessed genetic risk underlying 20 IBD-comorbidity associations using polygenic risk scores (PRS) in 853 patients with IBD (542 Crohn's...

Read the complete abstract on PubMed

Topics

Humans
Genetic Risk Score
Female
Comorbidity
Genetic Predisposition to Disease
Male
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Colitis, Ulcerative

Multifactorial Inheritance

Inflammatory Bowel Diseases

Adult

Risk Factors

Crohn Disease

Aged

Source

Identifiers

PMID: 42536096
DOI: 10.1007/s10620-026-10145-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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